In the year 2000, Doctor Annis Graduated from D'Annunzio University of Chieti–Pescara, Chieti, Italy where he also completed his medical training.

He undertook his initial training in Trauma and Orthopaedic surgery at Asklipieio Voula's Hospital, in Athens, Greece.

During his residency, he spent 6 months at the Spinal Department of the University of Utah in the USA where he developed his passion and skills in complex spinal surgery focused on preventing complications in Adult Spinal Deformity.

In the USA, he completed the AO Spine North America research fellowship and clinical spinal fellowship at the University of Utah, and there he gained experience in complex spinal surgery, from the skull to pelvis, dealing with the full spectrum of spinal pathologies, including the highly complex conditions of "degenerative scoliosis" and "fixed sagittal imbalance".

In 2014, he returned to Europe and was appointed as a spinal consultant at Royal University Hospital, Liverpool, England.

Currently, he is a consultant spinal surgeon and lead deformity surgeon at the Royal Liverpool University Hospital and the Walton Centre, Liverpool, Merseyside, United Kingdom. He holds an Honorary Contract with the University of Utah, USA as he is an Adjunct Faculty Instructor in Orthopaedics and Spinal Surgery and continues to work on numerous international spinal research projects there.

He also has a private practice with Spire Healthcare Group and Spire Murrayfield Hospitals, UK.

He published several peer-reviewed articles in internationally recognized scientific journals, presented his research findings at international conferences, and contributed chapters to various books in the established medical literature.

In 2012, he was recognized by the Scoliosis Research Society (SRS) with the famous Russel Hibbs Award.